Love and Hate for Imoen from Baldur's Gate. She's great at what she does, but is oh so super annoying. Would love to find the voice over girl for her and make her record different things in place of the annoying "I care not", "Do you wanna tell me a story...", and the ever so wonderful "I've done had enough of this."
StingingVelvet: Doctor Who companion Donna. If I met her in real life I would hate her guts, and she's super annoying. Yet at the same time there's something fun about the way she interacts with the Doctor that makes me consider her 10's best companion by far.
I've found no redeeming qualities in that shrew. I would have dropped her out of the TARDIS over an active volcano. But Rose what I would have done to that one, and I guess Mickey would have had to meet an unfortunate accident.