I thought this thread might help those who, like me, tend to become overly paranoid over PC security. I know there are gentlemen out there who don't believe in having that extra layer of security too, but let's just leave that argument out of this thread -- this thread is solely meant for people to post what anti-malware/spyware/virus software they have on their PC.
For me, I use CODOMO Free as my firewall, and Avast Free as my Antivirus. I also have SpywareBlaster, MalwareBytes Anti Malware and SuperAntiSpyware. I also use Mailwasher Free in addition to my Mozilla Thunderbird - Mailwasher lets you open up potentially risky emails from the server, without having any remote images downloaded on to your computer.

Used Avast for many years and it did me well. Light on resources and little or no problems as a result. Recently I switched to Microsoft Security Essentials so I have something more integrated with Windows and I like it so far. I've never used a firewall aside from Windows Firewall.

Microsoft Security Essentials on Windows 7, running as a regular user (not admin) with an admin password or 31 alpha-numeric non-dictionary password. All sensitive data stored in a Truecrypt volume with a different 28 char password.
This meets my needs as I don't usually install software and almost all of my work is done either in a VM or via RDP/SSH.
Also, the only place where the admin password is the same online is my Google Account.
Never had the need for anti-spyware software so far ever since the days of Win98SE.
I also purge my cookies regularly and the Windows temp file is under a non-standard location but doesn't matter anyway because, running as non-admin + UAC + MSE gives me the security I need without being a pain in the ass to manage.
Haven't had the need for a software firewall in ages and found most of them to be shit either way while the built-in one works great and doesn't fuck up all my remote connections.

Microsoft Security Essentials on Windows 7 on my laptop and my desktop. I don't work for the CIA (or DO I?!) so I don't really get all anal about security. I hate UAC but WIndows 7 makes it a lot easier but I still run as a admin. Firewall is whatever Windows comes with, because my router acts as a pretty good firewall itself. My password to login is about 7 characters long, all lowercase letters (whatever) but online I use passphrases translated into leetspeak with letters and numbers.
I haven't had the need for antispyware in ages but if I did I'd use HijackThis which is basically the nuclear option for clearing out your crap.

COMODO for a firewall, Avast for AV, and Firefox with NoScript to drastically reduce potential attack vectors. Also have some of the major ad severs (e.g. doubleclick) blackholed via my hosts file. Throw in basic good security practices like keeping things updated and just not doing stupid shit and I can't even remember the last time I had to deal with a virus or malware infection (must have been at least 7 years ago).

Avast and monthly reinstall. Or by-monthly. Or when something doesn't work. 'cause that always works :D

None, other than Firefox and the occassional harddisk wipe when I feel like it.

I just use Avast Free. Never find anything though.
It's michael isn't it?

Avira Premium Security Suite (32€ per year)
[url=]http://www.avira.com/en/products/avira_premium_security_suite.html[/url]
Since 4 years I have it, I now no longer need to reinstall my pc nor wipe an harddisk.

NOD32 AntiVirus, Windows Defender, Windows Firewall... Never had any problems with malicious software. I run as admin, without password and other crap, since I'm the only one who uses the lappy.

Microsoft Security Essentials for Windows 7, Avira Antivir Free Edition for Windows XP.

Well, for starters, anyone concerned about security should definitely be running a 64-bit version of Vista or 7, as the tighter protection for drivers and system files makes some of the nastier attack/injection vectors impossible. That's on top of vastly improved repair functionality of either flavour of Vista and newer which can let you roll Windows back to an earlier System Restore point even if Safe Mode is hosed (if even the repair mode is gone you can boot into it externally from an install or rescue disc).
Having a security suite which recognises digital signatures and file checksums is very useful for giving maximum protection with minimal nagging. Which leads us to:
This.
Comodo's free version has been inexplicably dubbed "Premium" for the latest release, but despite this it is still the same free, feature-rich product it has always been.
Comodo's antivirus component isn't as mature as Avast!'s, which is why it is still preferable for some purposes (especially malicious site blocking, which Comodo seems to currently lack). If you want a second opinion available you can install Comodo AV and then disable its live scanning. The definitions and such will still be updated, but it won't conflict with Avast!.
NoScript provides yet another layer of protection, protecting against all sorts of known and unknown attacks through its "default deny" JS model.

Nothing. Also, I disabled the driver protection crap (Win7 64bit), because it pissed me off to no end.

I used to have Avast AV (free) running until it expired. Was a bit lazy to re-register. When I did a reformat when I upgraded to a raptor about a year and a half ago, didn't bother to install it. So far, virus free!
And using Windows Defender since it's pushed via Windows Update.
(Running Win 7 64 Ultimate.)

ZoneAlarm Freee+Hardware router/firewall, Avira AntiVir, various antispyware software, Hijackthis, anti-rootkit, Adblock Plus on Firefox.
I used a HIPS software (Spyware Terminator) that gave me BSOD problems so I removed it. Now I'm planning to install another HIPS and I should be good to go...